Migraine-pathophysiology, clinical features, and modern therapy

Abstract

Migraine is a prevalent and disabling neurological disorder characterized by recurrent attacks of moderate to severe headache accompanied by various neurological, gastrointestinal, and autonomic symptoms. Affecting approximately 15% of the global population, migraine significantly impairs quality of life and contributes substantially to disability worldwide. Recent advances in understanding migraine pathophysiology have led to the development of targeted therapeutic approaches, particularly therapies directed against calcitonin gene-related peptide (CGRP). This article reviews the current understanding of migraine pathophysiology, clinical manifestations, diagnostic approaches, and contemporary treatment strategies.